Title: Jack of all trades: the molecular motor Dynein--how regulation can tune this amazing nanomachine
Inside of cells, there is a microtubule 'highway system', with directed transport towards the cell periphery ("plus-end") and also towards the cell center ("minus-end"). Almost all minus-end transport is carried out by the molecular motor dynein, which can act quite differently depending on which cargo is being transported where. I will discuss how dynein functions alone and in groups, and in particular describe our current understanding of how regulatory systems can alter its single-molecule properties in unexpected ways to achieve useful ensemble (group) function.
Every Friday 10:45-11:45 a.m., COB 267 (except as noted). Tea and cookies will be served from 10:30 - 10:45 a.m. Questions regarding the seminar series should be directed to Prof. Bin Liu